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Selected publications on the role of the noradrenergic system in ageing and dementia

  • Ludwig M, Yi YJ, Lüsebrink F, Callaghan MF, Betts MJ, Yakupov R, Weiskopf N, Dolan RJ, Düzel E, Hämmerer D. (2024) Functional locus coeruleus imaging to investigate an ageing noradrenergic system. doi: 10.1038/s42003-024-06446-5. PDF 

  • Leiman M, Ludwig M, Krohn F, Hämmerer D, Yi YJ. (2024) Cholinergic neuromodulation in the aging brain - Implications for neuropsychiatric diseases: Commentary on "neuromodulatory systems in aging and disease" special issue. doi: 10.1016/j.neubiorev.2024.105654. PDF

  • Yi YJ, Lüsebrink F, Ludwig M, Maaß A, Ziegler G, Yakupov R, Kreißl MC, Betts M, Speck O, Düzel E, Hämmerer D. (2023) It is the locus coeruleus! Or… is it?: a proposition for analyses and reporting standards for structural and functional magnetic resonance imaging of the noradrenergic locus coeruleus. doi: 10.1016/j.neurobiolaging. PDF

  • Lancini E, Haag L, Bartl F, Rühling M, Ashton NJ, Zetterberg H, Düzel E, Hämmerer D, Betts MJ. (2023) Cerebrospinal fluid and positron-emission tomography biomarkers for noradrenergic dysfunction in neurodegenerative diseases: a systematic review and meta-analysis. doi: 10.1093/braincomms/fcad085. PDF

  • Ehrenberg AJ, Kelberman MA, Liu KY, Dahl MJ, Weinshenker D, Falgàs N, Dutt S, Mather M, Ludwig M, Betts MJ, Winer JR, Teipel S, Weigand AJ, Eschenko O, Hämmerer D, Leiman M, Counts SE, Shine JM, Robertson IH, Levey AI, Lancini E, Son G, Schneider C, Egroo MV, Liguori C, Wang Q, Vazey EM, Rodriguez-Porcel F, Haag L, Bondi MW, Vanneste S, Freeze WM, Yi YJ, Maldinov M, Gatchel J, Satpati A, Babiloni C, Kremen WS, Howard R, Jacobs HIL, Grinberg LT. (2023) Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART. doi: 10.1002/alz.12937. PDF

  • Liebe, T., Kaufmann, J., Hämmerer, D., Betts, M., Walter, M. (2022) In vivo tractography of human locus coeruleus-relation to 7T resting state fMRI, psychological measures and single subject validity. Molecular Psychiatry, DOI: 10.1038/s41380-022-01761-x, PDF

  • Kathy Liu, Rogier A. Kievit, Kamen A. Tsvetanov, Matthew J. Betts, Emrah Düzel, James Rowe, Rob Howard, Dorothea Hämmerer. (2020) Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences. Nature communications, 11 (1), 1-9. PDF

  • Matthew J. Betts, Evgeniya Kirilina, Maria Otaduy, Dimo Ivanov, Julio Acosta-Cabronero, Martina Callaghan, Christian Lambert, Arturo Cardenas-Blanco, Kerrin Pine, Luca Passamonti, Clare Loane1, Max C. Keuken, Paula Trujillo, Falk Lüsebrink, Hendrik Mattern, Kathy Liu, Nikos Priovoulos, Klaus Fließbach, Martin J. Dahl, Anne Maaß, Christopher F. Madelung, David Meder, Alexander J. Ehrenberg, Oliver Speck, Nikolaus Weiskopf, Raymond Dolan, Ben Inglis, Duygu Tosun, Markus Morawski, Fabio A. Zucca, Hartwig Siebner, Mara Mather, Kamil Uludag, Helmut Heinsen, Benedikt A. Poser, Robert Howard, Luigi Zecca, James B Rowe, Lea T. Grinberg, Heidi I.L. Jacobs, Emrah Düzel*, Hämmerer, D*. (2019) Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain, 142, 2558-2571. *shared last PDF

  • Hämmerer, D ., Schwartenbeck, P., Gallagher, M., FitzGerald, T.H.B., Düzel, E. and Dolan, R.J. (2019) Older adults fail to form stable task representations during model-based inference. Neurobiology of Aging 74, 90-100.

  • Liu, K. Y., Acosta-Cabronero, J., Cardenas-Blanco, A., Betts, M. J., Kievit, R.A., Henson, R.N., Loane, C., Berry, A.J., Düzel, E., Cam-CAN, Howard, R., Hämmerer, D. In vivo visualization of age-related changes in the locus coeruleus (2019) Neurobiology of Aging 74, 101-111. PDF

  • Betts, M., Ehrenberger, A. J., Hämmerer, D., Düzel, E. (2018) Commentary: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice. Frontiers in Neuroscience 12, 401. PDF

  • Hämmerer, D., Callaghan, M.F., Hopkins, A., Kosciessa, J., Betts, M.., Cardenas-Blanco, A., Kanowski, M., Weiskopf, N., Dayan, P., Dolan, R.J. and Düzel, E. (2018) Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events. Proceedings of the National Academy of Sciences, 115 (9), 2228-2233. PDF

  • Hämmerer, D., Hopkins, A., Betts, M., Maaß, A., Dolan, R. J., Duzel, E. (2017) Emotional arousal and recognition memory are differentially reflected in pupil diameter responses during emotional memory for negative events in younger and older adults. Neurobiology of Aging, 58, 129-139. PDF

  • Liu, K.Y., Marijatta F., Hämmerer, D., Düzel E., Howard R.J. (2017) Magnetic resonance imaging of the human locus coeruleus: A systematic review. Neuroscience & Biobehavioral Reviews, 83, 325-355. PDF

  • Düzel, E., Guitart-Masip, M., Maass, A., Hämmerer, D., Betts, M. J., Speck, O., Weiskopf, N., Kanowski, M. (2015) Midbrain fMRI: Applications, Limitations and Challenges. In: fMRI: From Nuclear Spins to Brain Functions, BIological Magnetic Resonance, 581-609. PDF

Selected publications on changes in cognitive functions across the lifespan: Cognitive control
  • Hämmerer, D., Müller, V., Heekeren, H. R., Lindenberger, U., & Li, S.-C. (2014) Performance monitoring across the lifespan: Still maturing post-conflict regulation in children and declining task- set monitoring in older adults.Neuroscience & Biobehavioral Reviews, 46, 105-123. PDF

  • Hämmerer, D., Li, S.-C., Völkle, M., Müller, V., & Lindenberger, U. (2013). The reliability of event- related potentials related to performance monitoring across the lifespan. Psychophysiology. PDF

  • Papenberg, G., Hämmerer, D., Müller, V., Lindenberger, U., & Li, S.-C. (2013) Lower theta inter- trial phase coherence during performance monitoring is related to higher reaction time variability: A lifespan study. NeuroImage, 83, 912-920. PDF

  • Hämmerer, D., Li, S.-C., Müller, V., & Lindenberger, U. (2010). An electrophysiological study of response conflict monitoring across the lifespan: Assessing the roles of conflict monitoring, cue utilization, response anticipation, and response suppression. Neuropsychologia, 48, 3305-3316. PDF

  • Li, S.-C., Hämmerer, D., Müller, V., Hommel, B., & Lindenberger, U. (2009). Lifespan development of stimulus-response conflict cost: Similarities and differences between maturation and senescence. Psychological Research. 73(6), 777-785. PDF

Selected publications on changes in cognitive functions across the lifespan: Reinforcement learning
  • Fitzgerald, T. H. B., Hämmerer, D., Friston, K. J., Li, S.-C., Dolan, R. J. (2017) Sequential inference strategies correlate with individual differences in brain structures. PLOS Computational Biology, 13(5): e1005418. PDF

  • Hämmerer, D., Biele, G., Müller, V., Thiele, H., Nürnberg, P., Heekeren, H. R. & Li, S.-C. (2013) Striatal Dopamine Signaling and Outcome Updating across the Lifespan: The Effect of PPP1R1B (DARPP-32) Polymorphism on Event-related Potentials. Frontiers in Decision Neuroscience. 4(89). PDF

  • Hämmerer, D. & Eppinger, B. (2012) Dopaminergic and prefrontal contributions to learning and outcome monitoring during childhood and old age. Developmental Psychology, 48, 862-874. PDF

  • Eppinger, B., Hämmerer, D. & Li, S.-C. (2011) Neuromodulation of reward-based learning and decision making in human aging. Annals of the New York Academy of Sciences, 1235, 1-17. PDF

  • Hämmerer, D., Li, S.-C., Müller, V., & Lindenberger, U. (2011). Life span differences in electrophysiological correlates of monitoring gains and losses during probabilistic reinforcement learning. Journal of Cognitive Neuroscience, 23(3), 1-14. PDF

Selected publications on altering cognitive functions with non-invasive brain stimulation
  • Ludwig, M., Wienke, C., Betts, M., Zaehle, T., Hämmerer, D. (2021) Current challenges in reliably targeting the noradrenergic locus coeruleus using transcutaneous auricular vagus nerve stimulation (taVNS). Autonomic Neuroscience: Basic & Clinical, 236, 102900. PDF 

  • Hämmerer, D., Bonaiuto, J., Klein-Flügge, M., Bikson, M., Bestman, S. (2016) Biasing human value-based decision making with non-invasive brain stimulation. Nature Scientific Reports, 6:25160. PDF

  • Chen, J. A., Hämmerer, D., Strigaro, G., Liou, L.M., Tsai, C. H., Rothwell, J. C., Edwards, M. J. (2014) Domain-Specific Suppression of Auditory Mismatch Negativity with Transcranial Direct Current Stimulation. Clinical Neurophysiology, 125, 585-592. PDF

  • Chen, J. A., Hämmerer, D., Marshal, L., Strigaro, G., Liou, L.M., Tsai, C. H., Rothwell, J. C., Edwards, M. J. (2014) Bi-directional Modulation of Somatosensory Mismatch Negativity with Transcranial Direct Current Stimulation. Clinical Neurophysiology, 592, 745-757. PDF

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